Colorectal carcinoma (CRC) is a major cause of morbidity and mortality in Western countries.It has so far been molecularly defined mainly by alterations of the Wnt pathway.We show here for the Display Housing first time that aberrant activities of the signal transducer and activator of transcription STAT3 actively contribute to this malignancy and,

In mammals, the biological activity of the stem/progenitor compartment sustains production of mature gametes through spermatogenesis.Spermatogonial stem cells and their progeny belong to the Ball - Miscellaneous class of undifferentiated spermatogonia, a germ cell population found on the basal membrane of the seminiferous tubules.A large body of ev

The laboratory-scale (in-vitro) microbial fermentation based on screening of process parameters (factors) and statistical validation of parameters (responses) using regression analysis.The recent trends have shifted from full factorial design towards more complex response surface methodology designs such as Box-Behnken design, Central Composite des

Cell and tissue nanomechanics, being inspired by progress in high-resolution physical mapping, has recently burst into biomedical research, discovering not only new characteristics of normal and diseased tissues, but also unveiling previously unknown mechanisms of pathological processes.Some parallels can be drawn between early development and carc

The monitoring of both cold and warm season hydrologic processes in headwater watersheds is critical for accurate water resource monitoring in many alpine regions.This work presents a new method that explores the simultaneous use of remotely sensed surface soil moisture (SM) and snow depth (SD) Display Housing retrievals to improve hydrological mod